Dr. Greetje VANHOUTTE

e-mail

Telephone: (+32) 3 265 2793
Fax: (+32) 3 265 2774

Faculty of Pharmaceutical, Veterinary and Biomedical Sciences
Department of Biomedical Sciences

Address
Campus Drie Eiken, UC.116
Universiteitsplein 1, 2610 Wilrijk


RECENT RESEARCH TOPICS

The blood supply to an organ plays a crucial role in the physiological function and the energy metabolism of the tissue and is therefore also of clinical importance for the characterization of pathological features. The research work of Greet Vanhoutte involves the study of the regulation mechanism of the blood circulation system using in vivo MRI and this in different relevant animal models. From rat to mouse, different sequences are implemented to first study the rat tail as a thermoregulatory organ (MR angiography) followed by studying hypothalamus control of thermoregulation in the rat (fMRI: BOLD and CBV). Pathological outcome of the cerebral blood flow in transgenic mice (models for Amyotrophic Lateral Sclerosis and Alzheimer) is studied with EPI bolus tracking MRI.

Recent publications

• Neuroanatomical targets of reboxetine and bupropion as revealed by pharmacological magnetic resonance imaging.
  S. Sekar,J. Van Audekerke, G. Vanhoutte, A.S. Lowe, A.M. Blamire, A. Van der Linden, T. Steckler, M. Shoaib, M. Verhoye.
  Psychopharmacology (Berl). 2011 May 7. [Epub ahead of print]
• Labeling of luciferase/eGFP-expressing bone marrow-derived stromal cells with fluorescent micron-sized iron oxide particles improves quantitative and qualitative multimodal imaging of cellular grafts in vivo.
  N. De Vocht, I. Bergwerf, G. Vanhoutte, J. Daans, G. De Visscher, S. Chatterjee, P. Pauwels, Z. Berneman, P. Ponsaerts, A. Van der Linden.
  Mol Imaging Biol; in press. 2011.
• Neuroadaptive responses to citalopram in rats using pharmacological magnetic resonance imaging.
  S. Sekar, M. Verhoye, J. Van Audekerke, G. Vanhoutte, A.S. Lowe, A.M. Blamire, T. Steckler, A. Van der Linden, M. Shoaib.
  Psychopharmacology (Berl) 2011;213(2-3), p. 521-31.

• Clinical potential of intravenous neural stem cell delivery for treatment of neuro-inflammatory disease in mice?
  K.P. Reekmans, J. Praet, N. De Vocht, B.R. Tambuyzer, I. Bergwerf, J. Daans, V. Baekelandt, G. Vanhoutte, H. Goossens, P.G. Jorens, D.K. Ysebaert, S. Chatterjee, P. Pauwels, E. Van Marck, Z.N. Berneman, A. Van der Linden, P. Ponsaerts.
  Cell Transplant. in press.
• Validation of dementia models employing neuroimaging techniques.
  G. Vanhoutte, A. Campo, A. Van der Linden.
  In: Animal models of dementia. Eds. P.P. De Deyn & D. Van Dam, Humana Press 2011, p; 187-222.
• Reduction or inhibition of VEGF impairs vasoregulation by smooth muscle and autonomic nerve dysfunction.
  E. Storkebaum, S. Zacchigna, M. Meens, C. Ruiz de Almodovar, M. Mazzone, G. Vanhoutte, S. Vinckier, K. Poesen, D. Lambrechts, G.M.J. Janssen, G.E. Fazzi, P.M. Schiffers, A. Van der Linden, J.G.R. De Mey, P. Carmeliet.
  Circulation. 2010 Jul 20;122(3), p. 273-81.
• In vivo morphological changes in animal models of amyotrophic lateral sclerosis and Alzheimer's-like disease: MRI approach.
  P.R. Andjus, D. Bataveljić, G. Vanhoutte, D. Mitrecic, F. Pizzolante, N. Djogo, C. Nicaise, F. Gankam Kengne, C. Gangitano, F. Michetti, A. van der Linden, R. Pochet, G. Bacić.
  Anat Rec (Hoboken) 292:12(2009), p. 1882-92. (IF)
• Intraneuronal amyloid β and reduced brain volume in a novel APP T714I mouse model for Alzheimer's disease.
  B. van Broeck, G. Vanhoutte, D. Pirici, D. van Dam, H. Wils, I. Cuijt, K. Vennekens, M. Zabielski, A. Michalik, J. Theuns, P.P. de Deyn, A. Van der Linden, C. Van Broeckhoven, S. Kumar-Singh.
  Neurobiol Aging, 29:2(2008), p. 241-52
• Reduced brain volumes in mice expressing APP-Austrian mutation but not in mice expressing APP-Swedish-Austrian mutations.
  B. Van Broeck, G. Vanhoutte, I. Cuijt, S.Pereson, G. Joris, J.-P. Timmermans, A. Van der Linden, C. Van Broeckhoven, S. Kumar-Singh.
  Neurosci Lett 447:2-3(2008), p. 143-7.
• Bringing amyloid into focus with MRI microscopy.
  G. Vanhoutte and A. Van der Linden.
  Chapter 9.1: Textbook of in vivo Imaging in Vertebrates. Eds. V. Ntziachristos, A. Leroy-Willig & B. Tavitian, P233-6 (2007)
• Overexpression of human wildtype torsinA and human DeltaGAG torsinA in a transgenic mouse model causes phenotypic abnormalities.
  K. Grundmann, B. Reischmann, G. Vanhoutte, J. Hübener, P. Teismann, T.K. Hauser, M. Bonin, J. Wilbertz, S. Horn, H.P. Nguyen, M. Kuhn, S. Chanarat, H. Wolburg, A. Van der Linden, O. Riess.
  Neurobiol Dis 27:2(2007), p. 190-206
• Changing body temperature affects the T2* signal in the rat brain and reveals hypothalamic activity.
  G. Vanhoutte, M. Verhoye, A. Van der Linden.
  Magn Reson Med 55:5 (2006), p. 1006-12
• Intraneuronal amyloid β and reduced brain volume in a novel APP T714I mouse model for Alzheimer’s disease.
  B. Van Broeck, G. Vanhoutte, D. Piricia, D. Van Dam, H Wilsa, I. Cuijt, K. Vennekens, M. Zabielski, A. Michalik, J. Theuns, P.P. De Deyn, A. Van der Linden, C. Van Broeckhoven, S. Kumar-Singh.
  Neurobiol Aging 29:2(2006), p. 241-52.
• Non-invasive in vivo MRI detection of iron associated with neuritic plaques in APP[V717I] transgenic mice, a model for Alzheimer’s Disease.
  G. Vanhoutte, I. Dewachter, P. Borghgraef, F. Van Leuven, A. Van der Linden.
  Magn Reson Med 53:3(2005), p.607-13.
• Ammonia affects brain nitrogen metabolism but not hydration status in the Gulf toadfish (Opsanus beta).
  M. Veauvy Clémence, M.D. McDonald, J. Van Audekerke, G. Vanhoutte, N. Van Camp, A. Van der Linden, P.J. Walsh.
  Aquat Toxicol 74:1(2005), p. 32–46
• Assessment of the neovascular permeability in glioma xenografts by dynamic T1 MRI with Gadomer-17.
  M. Verhoye, B.P.J. van der Sanden, P.F.J.W. Rijken, H.P.W. Peters, A.J. Van der Kogel, G. Pée, G. Vanhoutte, A. Heerschap, A. Van der Linden.
  Magn Reson Med, 47:2(2002), p. 305-13.
• In vivo research of the thermoregulatory function of the rat tail studied with magnetic resonance angiography (MRA).
  G. Vanhoutte, M. Verhoye, E. Raman, M. Roberts, A. Van der Linden.
  NMR Biomed 15:4(2002), p. 263-9.
• An in vivo study of the thermoregulatory function of the rat tail using magnetic resonance angiography.
  G. Vanhoutte, M. Verhoye, E. Raman, M. Roberts, A. Van der Linden.
  Environmental Ergonomics IX, ED. W. Jurgen, Aachen, Shaker, 2000, p. 405-9.
• In vivo study of the thermoregulation of the rat tail using magnetic resonance angiography (MRA).
  G. Vanhoutte, M. Verhoye, E. Raman , A. Van der Linden.
  Medical Imaging 2000: Physiology and Function from Multidimensional Images, Eds. C.-T. Chen & A.V. Clough. Proceedings of SPIE vol. 3978, p. 466-75 (2000)
• Simultaneously recording of EEG/fMRI to study neurophysiological changes in rat brain during pentetrazol induced epileptic seizures.
  G. Vanhoutte, M. Verhoye, R.R. Peeters, J. Sijbers, J. Eelen, R. D'hooge, P.P. De Deyn, A. Van der Linden.
  Eur J Neurosci 12(2000), p. 107
• Quantification of tumour microvascular permeability in human glioma xenografts using dynamic T1 MRI with Gadomer-17.
  M. Verhoye, B.P.J. Van der Sanden, P. Rijken, H. Peters, A.J. Van der Kogel, G. Pee, G. Vanhoutte, A. Heerschap, A. Van der Linden.
  Proceedings of SPIE (International Society for Optical Engineering) Ed. K.M. Hanson, in 'Physiology and Function from Multidimensional Images', vol.3660, p. 418-28 (1999)

Academic bibliography

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